Gamebanshee has interviewed Obsidian devs Chris Avellone and Matt MacLean about their work on Alpha Protocol. While that must be very interesting to read, I only skimmed for news about Fallout: New Vegas. Here's what Chris Avellone had to say about that:
GB: During a recent interview, you stated that you, personally, were "all done" with Alpha Protocol. When did you actually switch gears to Fallout: New Vegas, and how difficult of a transition was it to go from modern espionage to the post-nuclear wasteland?
Chris: Like almost all the designers, I've moved off Alpha Protocol. Switching gears from Unreal to the GECK has been painless. All the previous experience with Fallout back at Black Isle studios also made the transition easy as well - we got right back in the saddle, and off we go.
On a different note, I hope they don't use any of the crappy voice actors from Fallout 3.
Read the whole interview here.