Todd Howard went on G4's X-Play and showed off Fallout 3. We actually get to see some real gameplay footage. Most of the footage is combat, but we do get to see the lockpicking minigame as well as lots of footage of the Pipboy. Definitely check it out here.
Edit: I don't have a TV, so I've never seen X-Play before, but god those guys are annoying.
Double Edit: How does a person explode by being hit with a teddy bear?