It's about a 20 minute video covering a few different games - the interview occurs between 8:30 and ends around 15:40 -
Most of it seems to be a rehash of past events and information - begins with referencing Patrick Stewart and Liam Neeson (The Emperor and your Father, Oblivion and Fallout 3, respectively)
Karma counts! - If you have compiled a "good" alignment, only good NPC's will join you, and vice versa.
Dogmeat will be your first joinable NPC, if you so choose.
Skill progression takes cues from Oblivion - the more "time you spend" on a specific skill, the higher it goes, rather than spending X amount of points in any way you choose when you level up.
Pete confirms that Fall 2008 will be the release season, with a set date due to be announced this summer. Simultaneous release for PC, XBOX360, PS3 - in the United States and Europe.
Once again Bethsoft confirms there will be no demo (this question has come up a lot lately, even though it's been answered numerous times) and hints that yes, there will be DL content - but that it isn't even being worked on as Bethesda Softworks is polishing what they do have, so they can release Fallout 3 on-time.