Just a quick thought:
I just saw the new trailer for the upcoming The Incredible Hulk movie with Edward Norton in the starring role. The trailer shows off Norton as the Hulk, and Tim Roth as Emil "The Abomination" Blonsky.
I hadn't really realized it before, but the Hulk in this trailer is way more along the lines of what I think a supermutant should look like, whereas The Abomination looks pretty much exactly like the Behemoth from Fallout 3. Is this Edward Norton's* subtle jab at the direction Bethesda's art department took for the new supermutants? You decide.
*Edward Norton may or may not be a rabid Fallout fan. We won't know until he comes here and tells us.